Ceshi Chen Selected Research

Factor V (Coagulation Factor V)

10/2021	Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer.
11/2019	USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5.
1/2019	Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers.
12/2018	Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis.
1/2018	Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1.
2/2017	Dexamethasone induces docetaxel and cisplatin resistance partially through up-regulating Krüppel-like factor 5 in triple-negative breast cancer.
8/2015	Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5).
9/2013	Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer.
1/2013	Role of KLF5 in hormonal signaling and breast cancer development.
7/2011	The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation.

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Ceshi Chen Research Topics

Disease

59	Neoplasms (Cancer) 01/2022 - 09/2002
53	Breast Neoplasms (Breast Cancer) 01/2022 - 09/2002
22	Triple Negative Breast Neoplasms 01/2022 - 09/2013
15	Carcinogenesis 11/2019 - 04/2003
7	Neoplasm Metastasis (Metastasis) 01/2022 - 04/2012
5	Prostatic Neoplasms (Prostate Cancer) 01/2013 - 04/2005
4	Carcinoma (Carcinomatosis) 10/2021 - 06/2009
4	Lung Neoplasms (Lung Cancer) 01/2020 - 07/2015
3	Hypoxia (Hypoxemia) 01/2021 - 01/2018
2	Liver Neoplasms (Liver Cancer) 01/2021 - 06/2012
2	Inflammation (Inflammations) 11/2018 - 01/2014
2	Infections 01/2018 - 01/2016
2	Pathologic Processes 01/2013 - 03/2006
2	Ductal Carcinoma 06/2009 - 06/2006
1	Colonic Neoplasms (Colon Cancer) 01/2021
1	Cysts 01/2021
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2021
1	Cachexia 01/2021

Drug/Important Bio-Agent (IBA)

25	Transcription Factors (Transcription Factor)IBA 01/2022 - 09/2002
16	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2005
12	UbiquitinIBA 01/2021 - 05/2005
10	Pharmaceutical PreparationsIBA 01/2022 - 10/2006
10	Factor V (Coagulation Factor V)IBA 10/2021 - 07/2011
10	Biomarkers (Surrogate Marker)IBA 06/2021 - 12/2007
10	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 04/2020 - 12/2005
9	Messenger RNA (mRNA)IBA 01/2022 - 09/2002
6	Kruppel-Like Transcription Factors (Kruppel-Like Factors)IBA 01/2022 - 04/2003
6	Ligases (Synthetase)IBA 01/2021 - 10/2006
6	Estrogen ReceptorsIBA 01/2020 - 06/2009
5	Small Interfering RNA (siRNA)IBA 01/2022 - 05/2006
5	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 01/2013
5	EnzymesIBA 01/2021 - 09/2019
4	Deubiquitinating EnzymesIBA 01/2022 - 08/2015
4	Transforming Growth Factor beta (TGF-beta)IBA 02/2016 - 06/2006
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022 - 04/2012
3	Phenobarbital (Luminal)FDA Link 01/2021 - 01/2016
3	Mifepristone (RU 486)FDA Link 01/2020 - 01/2016
3	Proline (L-Proline)FDA Link 01/2020 - 09/2019
3	Estrogens (Estrogen)FDA Link 01/2014 - 07/2011
2	Histone Deacetylase InhibitorsIBA 01/2022 - 09/2019
2	Long Noncoding RNAIBA 01/2022 - 01/2021
2	TriterpenesIBA 01/2021 - 01/2016
2	Econazole FDA LinkGeneric 01/2020 - 12/2017
2	oridoninIBA 11/2019 - 10/2016
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2019 - 02/2017
2	Biological ProductsIBA 01/2019 - 12/2007
2	GlucocorticoidsIBA 01/2019 - 02/2017
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2019 - 07/2006
2	Ursolic AcidIBA 02/2018 - 04/2017
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 12/2007
2	Indicators and Reagents (Reagents)IBA 04/2017 - 04/2012
2	lissamine rhodamine B (sulforhodamine B)IBA 02/2017 - 01/2013
2	AndrogensIBA 02/2016 - 01/2013
2	Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric 02/2016 - 12/2014
2	9,10-Dimethyl-1,2-benzanthraceneIBA 02/2016 - 12/2014
2	Hormones (Hormone)IBA 01/2016 - 01/2013
2	Therapeutic UsesIBA 01/2014 - 07/2006
2	Progesterone FDA LinkGeneric 01/2013 - 07/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2012 - 12/2007
2	Proteasome Endopeptidase Complex (Proteasome)IBA 06/2010 - 05/2005
1	Antisense OligonucleotidesIBA 01/2022
1	Y-Box-Binding Protein 1IBA 01/2022
1	AntigensIBA 01/2022
1	Protein Kinases (Protein Kinase)IBA 01/2022
1	Keratin-16 (Keratin 16)IBA 01/2022
1	polypeptide 3 90kDa ribosomal protein S6 kinaseIBA 01/2022
1	6-methyladenineIBA 01/2022
1	Tumor Biomarkers (Tumor Markers)IBA 01/2022
1	Tadalafil (Cialis)FDA Link 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	CXC ChemokinesIBA 01/2022
1	Mitogen-Activated Protein KinasesIBA 01/2022
1	ChromatinIBA 10/2021
1	CytokinesIBA 10/2021
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 10/2021
1	human PRMT2 proteinIBA 10/2021
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2021
1	Cysteine (L-Cysteine)FDA Link 01/2021
1	Cystine (L-Cystine)IBA 01/2021
1	MTOR InhibitorsIBA 01/2021
1	Lapatinib (GW572016)FDA Link 01/2021
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021
1	Fructose-Bisphosphate Aldolase (Aldolase)IBA 01/2021
1	pyrimidineIBA 01/2021
1	Ubiquitin-Activating Enzymes (Ubiquitin-Activating Enzyme)IBA 01/2021
1	Ubiquitin-Conjugating EnzymesIBA 01/2021
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2021
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 01/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2021
1	EphrinsIBA 01/2021
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021
1	Sirolimus (Rapamycin)FDA Link 01/2021
1	Amino Acids FDA Link 01/2021
1	PesticidesIBA 01/2021
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021

Therapy/Procedure

21	Therapeutics 01/2022 - 01/2013
4	Drug Therapy (Chemotherapy) 01/2021 - 02/2017
2	Immunotherapy 01/2022 - 10/2021
1	Enteral Nutrition (Feeding, Tube) 01/2021
1	Parenteral Nutrition 01/2021